HORDB

ID: hor002884
Uniprot ID: P17681
Protein name: Peptide 2
Gene name: NA
Organism: Aplysia fasciata (Mottled sea hare) (Aplysia brasiliana)
Family: NA
Source: animal
Expression: Neurons R3-R14. A cluster of 12 giant neurons located on the right side of the abdominal ganglion.
Disease: NA
Comments: NA
Taxonomy: Aplysia (genus), Aplysiidae (family), Aplysioidea (superfamily), Aplysiida (order), Tectipleura, Euthyneura, Heterobranchia (subclass), Gastropoda (class), Mollusca (phylum), Lophotrochozoa, Spiralia, Protostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
GO MF: NA
GO BP: GO:0007218 neuropeptide signaling pathway
GO CC: GO:0005576 extracellular region

Sequence: DAEEPSAFMTRL
Length: 12(29-40)
Propeptide: EEVFDDTDVGDELTNALESVLTDLKDKRDAEEPSAFMTRLRRQVAQMHIWRAVNHDRHHSTGSGRHSRFLTRNRYRYGGGHLSDA
Signal peptide: NA
Modification: NA
Glycosylation: NA
Mutagenesis: NA

Function: HRBP is a myoactive peptide that excites Aplysia heart and enhances gut motility in vitro.
Mechanism: NA
Cross BBB: NA
Target: NA
Target Unid: NA
IC50: NA
EC50: NA
ED50: NA
kd: NA
Half life: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

hor002884_AF2.pdb

hor002884_ESM.pdb

Mass:	156289	Formula:	C58H91N15O21S
Absent amino acids:	CGHIKNQVWY	Common amino acids:	AE
pI:	3.93	Basic residues:	1
Polar residues:	2	Hydrophobic residues:	4
Hydrophobicity:	-50	Boman Index:	-2936
Half-Life:	1.1 hour	Half-Life Yeast:	3 min
Half-Life E.Coli:	>10 hour	Aliphatic Index	49.17
Instability Index:	6603.33	Extinction Coefficient cystines:	0
Absorbance 280nm:	0

PubMed ID: 2587425
Title: Aplysia brasiliana neurons R3-R14: primary structure of the myoactive histidine-rich basic peptide and its prohormone.